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(1994) designated 1A1-3B (M17S2; 166945), and of a previously reported 295-bp intergenic region.Sequence analysis of the duplicated exons of BRCA1, 1A1-3B, and flanking genomic DNA revealed to 8700509]" pmid="8700509"Brown et al.Start here and get there by taking the e Harmony Personality Profile to see how you relate to other Santa Rosa singles.Then read your FREE Compatibility profile® and meet Santa Rosa singles that are truly right for you.Semiquantitative PCR detected variable and developmentally regulated expression of BRCA1-IRIS and full-length BRCA1 in several adult and fetal human tissues.
Unlike full-length BRCA1, BRCA1-IRIS was exclusively chromatin associated, failed to interact with BARD1 in vivo or in vitro, exhibited unique nuclear immunostaining, and coimmunoprecipitated with core DNA replication initiation sites and with replication initiation proteins.Suppression of BRCA1-IRIS hindered DNA replication, whereas overexpression stimulated DNA replication. (1996) determined the detailed structure of the BRCA1 genomic region.They showed that this region of chromosome 17 contains a tandem duplication of approximately 30 kb which results in 2 copies of BRCA1 exons 1 and 2, of exons 1 and 3 of the adjacent gene that 7997258] [Full Text]" pmid="7997258"Brown et al.Both BRCA1 and the granins localize to secretory vesicles, are secreted by a regulated pathway, are posttranslationally glycosylated, and are responsive to hormones.The authors stated that as a regulated secretory protein, BRCA1 appears to function by a mechanism not previously described for tumor suppressor products.El Shamy and Livingston (2004) identified a splice variant of BRCA1 that incorporates a unique 40-nucleotide first exon, exon 1c, that is located 24 Mb upstream of BRCA1 exons 1a and 1b.